The Silvertown Tunnel was closed northbound after an emergency services incident with drivers facing heavy congestion.
The road has since reopened but drivers continue being urged to find alternative routes.
Transport for London (TfL) states queues of traffic remain northbound from after A2 Sun in the Sands Roundabout.
Heavy traffic is also visible on all approaches to A102 Blackwall Tunnel Southern Approach and drivers can expect severe delays.
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